World Events

Nobel Prize in Medicine Awarded to Scientists Who Discovered Hepatitis C

Numerous life saving treatments have also been developed for the hepatitis C virus, many of which are in regular use today. When available, hepatitis C antivirals can block the virus from multiplying in the body, and can cure people of the infection in weeks. Researchers around the world are now at work on a vaccine that could prevent future hepatitis C virus infections and disease.

“For the longest time, we had nothing to treat this virus with,” said Dr. Guadalupe Garcia Tsao, a cirrhosis expert at Yale University. Preventing the disease, she added, was also nearly impossible without accurate tests. “For most of my career, it was the bane of my existence. But from the moment they made these discoveries, the numbers of sick people went down dramatically.”

Even hepatitis C drugs that originally failed to clear the approval pipeline have found new use in modern times: Remdesivir, one of only a handful of treatments with emergency authorization from the Food and Drug Administration to treat severely sick Covid-19 patients, was originally developed as an antiviral against the hepatitis C virus.

“That’s really the story of investing in basic science, and having it pay off later down the road,” said Stephanie Langel, a virologist and immunologist at Duke University.

Dr. Alter, an American, is a medical researcher for the National Institutes of Health in Maryland. Born in 1935 in New York, he earned a medical degree at the University of Rochester before joining the N.I.H. in 1961.

After treating some of the first “non-A, non-B” hepatitis patients decades ago, Dr. Alter expressed wonder at watching treatment for the illness evolve. Modern drugs can cure more than 95 percent of patients.

“I could never have imagined this, really, not in my lifetime,” he said Monday during a N.I.H. news conference.


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